Local modulation of basal forebrain: effects on working and reference memory
نویسندگان
چکیده
منابع مشابه
Local Modulation of Reference Memory Forebrain: Effects Working
The functional roles of the medial septal area (MSA) and nucleus basalis magnocellularis (NBM) in memory were investigated to determine (1) their relative contribution to working and reference memory, (2) their operation in spatial and nonspatial memory, (3) the temporal dynamics of the neural activity within these nuclei as they relate to mnemonic processes, (4) the neurochemical regulation of...
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15 صفحه اولRedundant basal forebrain modulation in taste aversion memory formation.
Mnemonic deficits resulting from excitotoxic lesion of the basal forebrain have been classically attributed to the resulting depletion of cortical acetylcholine activity. It has been demonstrated that in spite of the strong cholinergic depletion after injections into the basal forebrain of the immunotoxin 192IgG-saporin, no detectable deficit can be found in the acquisition of several learning ...
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BACKGROUND Dysfunction in prefrontal cortex (PFC) GABA transmission has been proposed to contribute to cognitive dysfunction in schizophrenia, yet how this system regulates different cognitive and mnemonic functions remains unclear. METHODS We assessed the effects of pharmacological reduction of GABAA signaling in the medial PFC of rats on spatial reference/working memory using different vers...
متن کاملLocal synaptic connections of basal forebrain neurons.
Single, biocytin filled neurons in combination with immunocytochemistry and retrograde tracing as well as material with traditional double-immunolabeling were used at the light and electron microscopic levels to study the neural circuitry within the basal forebrain. Cholinergic neurons projecting to the frontal cortex exhibited extensive local collaterals terminating on non-cholinergic, (possib...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1994
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.14-06-03578.1994